Grape Seed Extract procyanidins (Grape Seed Extract, Proanthocyanidin GSPE) is exist widely in plant kingdom belongs to the natural polyphenol compounds of double yellow ketone derivatives, these compounds are composed of different number of flavanols polymerization, in acidic solution heat generated white pigment (leucoanthocy anins) and procyanidins (proanthocy anidin), there are also called pycnogenols, the present study is the most widely exists in Grape Seed by 5, 7, 3', 4' -tetrahy flavan-3-o1 (5, 7, 3', 4' -tetrahy dro xyflavan-3-o1), i.e. (+)-catechin (+)-catechin, (-)-epicatechin (-)-epicatechin (-) -dinatechin), or proanic. It has a strong antioxidant property, which generally exists in the skin of fruits and the solid parts of plants. Its main function is to protect the easily oxidized components in plants. As early as the 1950s, French scientists discovered that large amounts of procyanidins could be extracted from pine bark, and the extract contained 85 percent procyanidins.
In the 1970s, grape seeds were found to be a better source for extracting procyanidins, which can be up to 95% in grape seed extracts. Physical and chemical properties and the physical and chemical properties with a white grape seed extract procyanidins extract powder, soluble in water, ethanol, methanol, acetone, also soluble in ethyl acetate, insoluble in ether, chloroform, benzene, etc. There are astringency. UV has strong absorption at 280nm. Heating in acid solution can degrade and oxidize to form anthocyanins (Bate -Smith reaction). Extraction and separation can be adopted such as methanol, ethanol, acetone polarity larger cold soak, solvent extract with ethyl acetate or other solvent extraction, the extraction with column chromatography separation methods, including glucan gel column chromatography, MCL - gel CHP - 20 p column chromatography, chiral adsorption column chromatography, high performance liquid chromatography, etc.